tacrine

Ligand id: 6687

Name: tacrine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 38.91
Molecular weight 198.12
XLogP 3.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Tacrine is used to treat mild dementia caused by Alzheimer's disease and other central nervous system disorders. Use has been discontinued in the US, as this drug has been superseded by alternative cholinesterase inhibitors.
Mechanism Of Action and Pharmacodynamic Effects
Tacrine prevents the breakdown of acetylcholine, ameliorating the effect of lower levels of this compound often observed in patients with dementia. Acetylcholine is important for the processes of memory, thinking, and reasoning.
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