cabazitaxel

Ligand id: 6798

Name: cabazitaxel

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View more information in the IUPHAR Pharmacology Education Project: cabaitaxel

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 15
Hydrogen bond donors 3
Rotatable bonds 16
Topological polar surface area 202.45
Molecular weight 835.38
XLogP 5.18
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in combination with prednisone to treat prostate cancer that has progressed after treatment with other anti-cancer medicines, including docetaxel.
Mechanism Of Action and Pharmacodynamic Effects
Like docetaxel, cabazitaxel reversibly binds to microtubules with high affinity, hyper-stabilising their structure and limiting the flexibility of the cell's cytoskeleton, thus compromising cell growth, division and ultimately viability.