leflunomide

Ligand id: 6825

Name: leflunomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.13
Molecular weight 270.06
XLogP 3.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat active rheumatoid arthritis (improve physical function and slow progression), prevention of acute/chronic rejection following organ transplant (as an FDA designated orphan drug).
Mechanism Of Action and Pharmacodynamic Effects
Leflunomide acts as a pyrimidine synthesis inhibitor. It is rapidly and almost completely metabolized following oral administration to its pharmacologically active metabolite, A77 1726. Its mechanism of action has not been fully resolved but appears to be associated with a reduction in the pyrimidine level, which in turn has an inhibitory effect on autoimmune T cells [1].