trastuzumab emtansine

Ligand id: 6928

Name: trastuzumab emtansine

No information available.
Summary of Clinical Use
The antibody portion of this drug is known as Herceptin and is used on its own to treat erbB2 positive breast cancers. This conjugated drug has the additional effect of bringing a highly cytotoxic drug to these very specific cancer cells.
Mechanism Of Action and Pharmacodynamic Effects
Upon binding, the drug is internalised, the cytotoxic agent is cleaved and is then available to bind to tubulin. The cytotoxic effect is via disruption of tubulin polymerisation (microtubule formation) and leads to cell cycle arrest and cell death.