Ligand id: 6981

Name: amlodipine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: amlodipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 99.88
Molecular weight 408.15
XLogP 3.25
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension and chronic stable angina.
Amlodipine is a component of the fixed-ratio drug Caduet® (marketed as Envacar® in some countries) which also contains the HMG-CoA inhibitor atorvastatin. Caduet® was first approved by the US FDA in 2004.
Amlodipine is also a component of Prestalia®, a mixture of amlodipine and perindopril, a drug approved (by the US FDA in 2015) for the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects
For an overview of the mechanism of action of amlodipine, please use the DrugBank link on the Summary tab.