romidepsin

Ligand id: 7006

Name: romidepsin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: romidepsin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 193.3
Molecular weight 540.21
XLogP 3.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Romidepsin is approved to treat cutaneous T-cell lymphoma (CTCL).
Mechanism Of Action and Pharmacodynamic Effects
Romidepsin is thought to be a prodrug which releases a zinc-binding thiol upon intracellular reduction. It is this thiol which interacts with the zinc atom in the binding pocket of the histone deacetylase, an interaction which blocks histone deacetylase activity and ultimately induces cell cycle arrest and apoptosis of cancer cells.
External links