nitroglycerin

Ligand id: 7053

Name: nitroglycerin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nitroglycerin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 157.11
Molecular weight 227
XLogP 0.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat angina
Mechanism Of Action and Pharmacodynamic Effects
Nitroglycerin is converted to nitric oxide (NO). This activates soluble guanylyl cyclase which in turn increases cGMP synthesis, leading to a downstream release of calcium ions and finally relaxation of the smooth muscle cells and vasodilation.