beclometasone

Ligand id: 7059

Name: beclometasone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 408.17
XLogP 1.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used for the prophylaxis of asthma. However, there is no information regarding approval for use of this drug on the US FDA or European Medicines Agency websites, although the compound does have an INN. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Beclometasone is a glucocorticoid receptor (GR) agonist. By binding to this receptor, inhibition of leukocyte filtration at the site of inflammation occurs, along with interference of the function of inflammatory mediators and suppression of humoral immune responses. Beclometasone dipropionate, once converted to its active drug beclometasone, therefore induces an antiinflammatory response.