clobetasol propionate

Ligand id: 7062

Name: clobetasol propionate

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View more information in the IUPHAR Pharmacology Education Project: clobetasol propionate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 80.67
Molecular weight 466.19
XLogP 2.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat skin inflammation and itching caused by conditions such as allergic reactions, eczema, and psoriasis.
Mechanism Of Action and Pharmacodynamic Effects
As an agonist of the glucocorticoid receptor (GR), clobetasol modulates expression of genes containing the glucocorticoid response element (GRE). Although complex, the response appears to include inhibition of the biosynthesis of pro-inflammatory prostaglandins and leukotrienes.
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