diflorasone diacetate

Ligand id: 7068

Name: diflorasone diacetate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 106.97
Molecular weight 494.21
XLogP 2.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to reduce skin inflammation caused by allergic reactions, eczema and psoriasis.
Mechanism Of Action and Pharmacodynamic Effects
As an agonist of the glucocorticoid receptor, diflorasone modulates expression of genes containing the glucocorticoid response element (GRE). Although complex, the response appears to include inhibition of the biosynthesis of pro-inflammatory prostaglandins and leukotrienes.
External links