doxorubicin

Ligand id: 7069

Name: doxorubicin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: doxorubicin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 6
Rotatable bonds 5
Topological polar surface area 206.07
Molecular weight 543.17
XLogP -1.68
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Doxorubicin is indicated for treatment of breast and ovarian cancers, multiple myeloma and Kaposi sarcoma.
Mechanism Of Action and Pharmacodynamic Effects
Doxorubicin disrupts DNA function and replication, by directly intercalating into the DNA structure, and by inhibiting the progression of topoisomerase II, an enzyme essential for transcription and DNA replication. This DNA damage leads to apoptotic cell death.
External links