flunisolide

Ligand id: 7076

Name: flunisolide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 93.06
Molecular weight 434.21
XLogP 1.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Flunisolide use is indicated to prevent asthma attacks and to treat allergic rhinitis.
Mechanism Of Action and Pharmacodynamic Effects
As an agonist of the glucocorticoid receptor, flunisolide modulates expression of genes containing the glucocorticoid response element (GRE). Although complex, the response appears to include inhibition of the biosynthesis of pro-inflammatory prostaglandins and leukotrienes.