rescinnamine

Ligand id: 7098

Name: rescinnamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 117.78
Molecular weight 634.29
XLogP 3.39
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation. The Drugs.com International Drug Names list suggests this drug is only available in Taiwan.
Mechanism Of Action and Pharmacodynamic Effects
Rescinnamine competes with angiotensisn I for binding to ACE thereby inhibiting its enzymatic conversion to angiotensin II. Reduced levels of angiotensin II leads to reduced blood pressure by modulating the renin-angiotensin system (RAS).