altretamine

Ligand id: 7112

Name: altretamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 48.39
Molecular weight 210.16
XLogP 0.29
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a second-line treatment for some cases of ovarian cancer.
Mechanism Of Action and Pharmacodynamic Effects
As a DNA alkylating (cross-linking) agent, altretamine treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
External links