amlexanox

Ligand id: 7113

Name: amlexanox

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 102.51
Molecular weight 298.1
XLogP 3.35
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat asthma and allergic rhinitis in Japan and was approved in the US to treat aphthous ulcers [1]. Use of this drug is not currently approved in the US (old formulations have been discontinued) or EU. Other national approval agencies may continue to grant marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Amlexanox's mechanism of action is not well-determined, but likely includes inhibition of histamine and leukotriene release [1], and possibly inhibition of phosphodiesterase [3-4]. Since PDE4 is prevalent in immune cells [6], this may be a target of amlexanox (see the CHEMBL link).
External links