benzthiazide

Ligand id: 7125

Name: benzthiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 160.75
Molecular weight 430.98
XLogP 2.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension and edema.
Mechanism Of Action and Pharmacodynamic Effects
Reduces water retention by inhibiting Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys by inhibiting the Na-Cl symporter SLC12A3.