busulfan

Ligand id: 7136

Name: busulfan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 103.5
Molecular weight 246.02
XLogP -1.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Busulfan is used as palliative care in patients with chronic myeloid leukemia (CML). It is also used to pre-condition (ie immunosuppress) patients prior to undergoing bone marrow transplant (autologous or allogenic hematopoietic stem cell transplantation) as treatment for leukemias.
Mechanism Of Action and Pharmacodynamic Effects
As a DNA alkylating (cross-linking) agent, busulfan treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
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