butabarbital

Ligand id: 7137

Name: butabarbital

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 82.25
Molecular weight 212.12
XLogP 2.5
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat insomnia, or as a pre-surgical sedative.
Mechanism Of Action and Pharmacodynamic Effects
Binds to the CNS GABAA Cl- channel, increasing inhibitory GABAergic tone.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
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