chlorambucil

Ligand id: 7143

Name: chlorambucil

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 40.54
Molecular weight 303.08
XLogP 4.29
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Chlorambucil is used to treat Hodgkin's disease and some types of leukemia or lymphoma.
Mechanism Of Action and Pharmacodynamic Effects
As a DNA alkylating (cross-linking) agent, chlorambucil treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
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