cyclophosphamide

Ligand id: 7154

Name: cyclophosphamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 51.38
Molecular weight 260.02
XLogP 0.84
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an antineoplastic agent to treat various malignancies. This drug is also used to treat certain cases of pediatric nephrotic syndrome (kidney disease) and as an immunosuppressant to control rejection following organ or bone marrow transplantation..
Mechanism Of Action and Pharmacodynamic Effects
As a DNA alkylating (cross-linking) agent, cyclophosphamide treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
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