ethopropazine

Ligand id: 7181

Name: ethopropazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 31.78
Molecular weight 312.17
XLogP 5.31
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat the dyskinesia typical of Parkinson's disease. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
By antagonising the muscarinic acetylcholine M1 receptor, ethopropazine is believed to correct the imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum associated with Parkinsonism.