ifosfamide

Ligand id: 7201

Name: ifosfamide

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View more information in the IUPHAR Pharmacology Education Project: ifosfamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 51.38
Molecular weight 260.02
XLogP 0.84
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in various combined chemotherapy treatments to treat different cancers, including testicular cancer, ovarian and cervical cancers, soft tissue sarcomas, osteosarcoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
Mechanism Of Action and Pharmacodynamic Effects
As a DNA alkylating (cross-linking) agent, ifosfamide treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
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