labetalol

Ligand id: 7207

Name: labetalol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 5
Rotatable bonds 8
Topological polar surface area 96.57
Molecular weight 328.18
XLogP 5.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Labetalol anatgonises both α- and β-adrenoceptors in the sympathetic system. This prevents the receptors from processing signals from eondogenous epinephrine and norepinephrine resulting in decreased force of heart contractions and lowered heart rate (antagonism of myocardial β1-adrenoceptors), bronchodilation (α1- and β2-adrenoceptors) and vascular smooth muscle relaxation (α1-adrenoceptors). See the DrugBank link for further details.