lomustine

Ligand id: 7214

Name: lomustine

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View more information in the IUPHAR Pharmacology Education Project: lomustine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 65.26
Molecular weight 233.09
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Lomustine is used to treat brain and lung tumors, metastatic melanoma and Hodgkin's disease. This drug is generally used clinically in combination with radiotherapy and/or surgery.
Mechanism Of Action and Pharmacodynamic Effects
As a DNA alkylating (cross-linking) agent, lomustine treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
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