metharbital

Ligand id: 7230

Name: metharbital

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 69.97
Molecular weight 198.1
XLogP 0.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat epilepsy. However, there is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Metharbital can positively modulate the activity of GABAA anion channels. The drug increases inhibitory GABAergic tone and causes neuro-inhibition. Drug-induced effects are observed clinically as anxiolytic, sedative, anticonvulsant and skeletal muscle relaxant actions.