procarbazine

Ligand id: 7278

Name: procarbazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 53.16
Molecular weight 221.15
XLogP 2.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a component of treatment for Hodgkin's disease (lymphadenoma) and some other cancers.
Mechanism Of Action and Pharmacodynamic Effects
As a DNA alkylating (cross-linking) agent, procarbazine treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. The drug may have additional actions, see the DrugBank link for further details. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
External links