quinethazone

Ligand id: 7289

Name: quinethazone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 113.16
Molecular weight 289.03
XLogP 0.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Reduces water retention by inhibiting Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys by inhibiting the Na-Cl symporter SLC12A3. This helps to reduce blood pressure.