tolazoline

Ligand id: 7310

Name: tolazoline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 24.39
Molecular weight 160.1
XLogP 3.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a vasodilator, to treat vasoconstriction in the pulmonary arteries. FDA marketing authorisation has been discontinued and the EMA does not approve use of this drug in the EU. Other national approval agencies may continue to grant marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
The precise mechanisms underlying the beneficial clinical effects of this drug are not clear. It has anti-adrenergic activity at α-adrenoceptors which likely accounts for the vasodilatory effect [2]. Drug-induced histamine release via activation of the histamine H1 receptors may synergise with the adrenergic vasodilatory effect. See the DrugBank link for further details.