trihexyphenidyl

Ligand id: 7315

Name: trihexyphenidyl

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 23.47
Molecular weight 301.24
XLogP 5.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug is an antiparkinsonism agent, often used alongside levodopa.
Mechanism Of Action and Pharmacodynamic Effects
Trihexyphenidyl blocks efferent impulses in parasympathetically innervated structures like smooth muscles, by antagonising M1 muscarinic receptors [2].
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