aleglitazar

Ligand id: 7405

Name: aleglitazar

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 110.03
Molecular weight 437.13
XLogP 5.87
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The hope for this drug is that it would reduce cardiovascular mortality and morbidity in patients with type II diabetes mellitus.
Mechanism Of Action and Pharmacodynamic Effects
Aleglitazar is an agonist of the PPARs, PPARα and PPARγ. Activation of PPARα controls circulating lipid levels and PPARγ controls glucose levels and improves insulin sensitivity. These comined effects are intended to improve both glucose control and heart health in type II diabetics.