Synonyms: PF-00734200
Compound class:
Synthetic organic
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
Gosogliptin is an experimental dipeptidyl peptidase 4 (DPP4) inhibitor. DPP4 inhibitors are used to treat type 2 diabetes. |
Mechanism Of Action and Pharmacodynamic Effects |
Gosogliptin is a selective oral dipeptidyl peptidase-4 (DPP4) inhibitor. Inhibition of this enzyme increases levels of glucagon-like peptide 1 (GLP-1). This in turn, inhibits glucagon production from pancreatic α-cells and increases production of insulin from pancreatic β-cells. |