moclobemide

Ligand id: 7428

Name: moclobemide

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View more information in the IUPHAR Pharmacology Education Project: moclobemide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 41.57
Molecular weight 268.1
XLogP 1.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat depression and social anxiety disorder. However, there is no information regarding marketing approval for this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Moclobemide is a reversible monoamine oxidase A (MAO-A) inhibitor (aka RIMA). Inhibition of MAO-A reduces catabolism of central serotonin, noradrenaline and dopamine. The resulting elevated levels of these neurotransmitters in and around neuronal synapses is responsible for the clinical antidepressant efficacy. RIMAs have antidepressant efficacy with less risk of fatal side-effects, such as hypertensive crisis.
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