indacaterol

Ligand id: 7455

Name: indacaterol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 81.59
Molecular weight 392.21
XLogP 5.19
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Indacaterol is a very long-acting, rapid onset β2-adrenoceptor agonist [2] approved for the once-daily management of asthma and chronic obstructive pulmonary disease (COPD).
A fixed-dose inhalation combination medicine containing incadaterol and glycopyrrolate (Utibron Neohaler) was approved by the US FDA in November 2015 for the treatment of COPD
Mechanism Of Action and Pharmacodynamic Effects
Indacaterol is a highly potent and selective β2-adrenoceptor agonist which acts locally in the lung as a bronchodilator when applied as an inhaled drug. Agonist-induced elevated cAMP levels cause relaxation of bronchial smooth muscle.
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