bendamustine

Ligand id: 7478

Name: bendamustine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 58.36
Molecular weight 357.1
XLogP 3.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to treat chronic lymphocytic leukemia [1] and lymphomas (eg indolent B-cell non-Hodgkin lymphoma).
Mechanism Of Action and Pharmacodynamic Effects
Bendamustine is a DNA alkylating agent. The drug irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death.