phenazopyridine

Ligand id: 7616

Name: phenazopyridine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 89.65
Molecular weight 213.1
XLogP 3.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Phenazopyridine acts as a local anesthetic when excreted into the urinary bladder. It has been used to alleviate the symptoms of pain, burning, urgency, frequency, and other discomforts resulting from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, or other conditions and procedures that irritate the bladder. This drug is availalbe with or without prescription in the US.
Mechanism Of Action and Pharmacodynamic Effects
It has been reported that phenazopyridine can directly inhibit sensory Aδ-fibers in normal rat bladder [1], although some caveats to the experimental methodology are discussed in [2]. Aδ-fibers respond to stimuli such as cold and pressure and also act as nociceptors. Inhibition of these fibres could explain the local anaesthetic-like effect of phenazopyridine in the urinary bladder.
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