testosterone phenylpropionate

Ligand id: 7628

Name: testosterone phenylpropionate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 43.37
Molecular weight 420.27
XLogP 8.1
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Testosterone phenylpropionate is one of the ingredients of the approved fixed-mixture drug Sustanon®, which contains four esterized testosterone compounds (testosterone phenylpropionate, testosterone propionate, testosterone isocaproate and testosterone decanoate) and is designed to provide sustained release of drug in to the bloodstream and more stable serum testosterone levels. This drug mixture is used for testosterone replacement therapy in males with conditions associated with primary and secondary hypogonadism, either congenital or acquired and may also be used as supportive therapy for female-to-male transsexuals. Sustanon® is an anabolic steroid product used illicitly by bodybuilders and athletes to build muscle mass. Sustanon® was first approved in the UK in 1973 (eMC link).
Mechanism Of Action and Pharmacodynamic Effects
Testosterone binds to the androgen receptor (AR), and the ligand-receptor complex translocates to the nucleus and binds to androgen response elements (AREs) on chromosomal DNA, thereby modulating transcription of a set of androgen-responsive genes. Testosterone can also be converted to estrogen and has a similar regulatory action on genes containing estrogen response elements (EREs).