florbetaben

Ligand id: 7769

Name: florbetaben    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 39.72
Molecular weight 359.19
XLogP 5.7
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Florbetaben is approved as a tool to help identify the presence of amyloid-β (Aβ) as a diagnostic biomarker in the brains of patients with Alzheimer's disease (AD) [1].
Mechanism Of Action and Pharmacodynamic Effects
Intravenously administered florbetaben crosses the blood-brain-barrier where it selectively binds to the Aβ contained in the plaques that are hypothesised to be mechanistically involved in the development of Alzheimer's disease. The 18F radioactive tracer can then be detected by PET scanning and its accumulation and distribution computationally analysed.
External links