Compound class:
Synthetic organic
Comment: Remodelin is a reported to be an inhibitor of acetyl-transferase NAT10 (Q9H0A0) and gets its name from its ability to restore nuclear morphology in lamin A-depleted cells.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
Remodelin corrects nuclear shape defects of laminopathic cells (human lamin A/C-depleted cells and cells derived from patients with Hutchinson-Gilford progeria syndrome) [1]. It is postulated that this remodelin effect occurs via NAT10-induced microtubule reorganisation. Remodelin represenrts a novel strategy for correcting the nuclear abnormalities associated with laminopathies and aging. |