Ligand id: 8173

Name: CEP-1374

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 145.32
Molecular weight 615.19
XLogP 4.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
CEP-1374 blocks the activation of -Jun n-terminal kinases (JNKs) by inhibiting upstream mixed lineage kinases (MLKs) [3]. Inhibition of the JNK pathway is proposed to provide neuroprotective effects which may delay the progression of motor dysfunction in neurodegenerative conditions such as Parkinson's disease [2,4].