chlorpromazine

Ligand id: 83

Name: chlorpromazine

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View more information in the IUPHAR Pharmacology Education Project: chlorpromazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 31.78
Molecular weight 318.1
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Antipsychotic used in the treatment of schizophrenia and the manic phase of bipolar disorder. May also be used to treat porphyria, tetanus, nausea and vomiting, hiccups and some behavioural problems in children.
Mechanism Of Action and Pharmacodynamic Effects
Chlorpromazine has antagonistic action across a variety of CNS postsysnaptic receptor systems, including dopamine, serotonin, histamine, adrenergic and muscarinic receptors. Each of these receptor pathways accounts for different aspects of the drug action. For example, sedative and antiemetic actions may arise via antagonism of histamine receptors and anxiolytic, antidepressive and antiaggressive properties may be attributable to antagonism of serotonin 5HT1 and 5HT2 receptors. More detail is available in the DrugBank entry for this ligand, accessible on the Summary tab of this ligand page.