compound 4d [PMID: 25489658]

Ligand id: 8483

Name: compound 4d [PMID: 25489658]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 52.6
Molecular weight 391.95
XLogP 5.56
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Kallikrein inhibitors are being investigated as novel therapeutics for certain skin diseases such as Netherton syndrome, an autosomal recessive disorder caused by deficiency of the endogenous serine protease inhibitor lympho-epithelial Kazal-type-related inhibitor (LEKTI- protein product of the SPINK5 gene) [1]. Deficiency of such endogenous inhibitors results in unopposed serine protease activity which can have a pathological outcome. Hence the development of serine protease inhibitors with clinical utility.