CC-220

Ligand id: 9618

Name: CC-220

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 88.18
Molecular weight 449.2
XLogP 1.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
CC-220 is being evaluated in clinical trials for systemic lupus erythematosus (SLE; Phase 2), and for relapsed and refractory multiple myeloma (alone or in combination with dexamethasone (Phase 1/2).
Mechanism Of Action and Pharmacodynamic Effects
CC-220 binding to cereblon promotes CRL4-CRBN E3 ligase-mediated degradation of the DNA-binding proteins Ikaros (IKZF1) and Aiolos (IKZF3), which are two cereblon substrates [3]. The downstream effects of degrading these proteins mediate the antiproliferative and immunomodulatory activities of cereblon-binding drugs [1]. Polymorphisms of the IKZF3 gene have been associated with systemic lupus erythematosus in a Chinese Han population [2].