Synonyms: Corectim® | ent-60 [4] | JTE-052 | JTE052
delgocitinib is an approved drug (Japan (2020))
Compound class:
Synthetic organic
Comment: Delgocitinib (JTE-052) is an ATP-competitive pna-Janus kinase (JAK) inhibitor in development for anti-inflammatory potential [5]. The chemical structure is disclosed in [4]. The pharmacology of JTE-052 was previously reported in [5]. Based on the developer's pipeline and patent claims, and on the structure submitted to the WHO for the INN delgocitinib, JTE-052 is likely to be compound 6 as claimed in patent US20140187534 [3]. Compound 6 is the most potent (lowest IC50) optically active stereoisomer with the correct structure in the patent, although stereochemistry has not rendered unambiguously in the patent extraction, and an IUPAC name is not provided.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
The developer's (Japan Tobacco Inc.) pipeline update in May 2017 listed JTE-052 as being in Phase 2 clinical development. As of September 2018, ClinicalTrials.gov lists one delgocitinib (JTE-052) clinical trial, NCT03683719 (sponsored by LEO Pharma), which is designed as a dose-finding, placebo-controlled study in patients with chronic hand eczema. In January 2020 topical delgocitinib was approved in Japan, for the treatment of atopic dermatitis [1], with Phase 3 results being published by Nakagawa et al. 3 months later [2]. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT03683719 | Phase 2b Dose-ranging Trial to Evaluate Delgocitinib Cream 1, 3, 8, and 20 mg/g Compared to Delgocitinib Cream Vehicle Over a 16-week Treatment Period in Adult Subjects With Chronic Hand Eczema | Phase 2 Interventional | LEO Pharma | ||
NCT02664805 | Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema | Phase 2 Interventional | LEO Pharma | 6 |