ruxolitinib

Ligand id: 5688

Name: ruxolitinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 83.18
Molecular weight 306.16
XLogP 1.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Disease
Disease X-Refs Comment References
Myelofibrosis Disease Ontology: DOID:4971
OMIM: 254450
Orphanet: ORPHA824
Approved drug for myelofibrosis, in particular for primary myelofibrosis, post-polycythemia vera (post-PV) myelofibrosis and post-essential thrombocythemia (post-ET) myelofibrosis.
Polycythemia vera Disease Ontology: DOID:8997
OMIM: 263300
Orphanet: ORPHA729
Approved in 2014 for this indication.