IL-17B

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Ligands
IL-17B (Human)

GtoPdb Ligand ID: 5877

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-17B is a proinflammatory homolog of IL-17 expressed at very high levels in spinal cord (primarily localizing to neuronal cell bodies and axons) and at lower levels in trachea, prostate, lung, small intestine, testes, adrenal, and pancreas [2-3], and acting on a restricted set of target cells (IL-17B receptor expression is restricted to human kidney, pancreas, liver, brain, and intestines [3]).

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
IL-17B signaling via the IL-17B receptor [3] plays a key role in development, progression and metastasis of certain cancers (e.g. breast [1] and pancreatic [4] cancers), suggesting an alternative interventional target for these diseases.

Immunopharmacology Comments

IL-17B signaling via the IL-17B receptor [3] plays a key role in development, progression and metastasis of certain cancers (e.g. breast [1] and pancreatic [4] cancers), suggesting an alternative interventional target for these diseases.