BMS-561392

Ligand id: 6509

Name: BMS-561392

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 117.78
Molecular weight 476.24
XLogP 4.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Disease
Disease X-Refs Comment References
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
An investigational ADAM17 inhibitor with potential to reduce TNFα production in TNF-driven conditions such as RA.
Inflammatory bowel disease 1; IBD1 Disease Ontology: DOID:0050589
OMIM: 266600
An investigational ADAM17 inhibitor with potential to reduce TNFα production in TNF-driven conditions such as RA.