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Synonyms: IMCgp100 | Kimmtrak® | tebentafusp-tebn
tebentafusp is an approved drug (FDA & EMA (2022))
Compound class:
Antibody
Comment: Tebentafusp (IMCgp100) is an immunotherapeutic antibody/peptide fusion, comprising a soluble T cell receptor (TCR) specific for the HLA-A2 restricted melanoma-associated antigen gp100, fused to an anti-CD3 single chain antibody fragment (scFv) [1,3-4]. This belongs to a novel class of immunotherapeutics termed ImmTACs (Immune Mobilising mTCR against Cancer) which are designed to restore immune surveillance and T-cell-directed killing of specific cancer cells.
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| Immunopharmacology Comments |
| MCgp100 is an immunotherapeutic that has been designed to override immune tolerance to certain cancer cells and mobilise T cells to kill them. |
