Compound class:
Endogenous peptide in human, mouse or rat
Comment: CCL7 is a CC family chemokine, most closely related to CCL2.
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Immunopharmacology Comments |
| CCL7 acts via the chemokine receptors CCR1, CCR2, CCR3 and CCR6. to recruit monocytes to sites of inflammation. It has regulatory action vs. macrophages. MMP2-catalysed cleavage of CCL7 creates a peptide with chemokine receptor antagonist activity that dampens inflammation [6]. |
