Synonyms: PF-00547659 | PF-547659 | SHP647
Compound class:
Antibody
Comment: Ontamalimab (PF-00547659) is a fully human, IgG2, investigational monoclonal antibody targeting mucosal addressin cell adhesion molecule 1 (MADCAM1) [1-2]. It is being evaluated for clinical potential in inflammatory bowel diseases. PF-00547659 was granted FDA orphan drug designation for ulcerative colitis in November 2017.
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Immunopharmacology Comments |
MAdCAM-1 binding by PF-00547659 selectively reduces lymphocyte homing to the intestinal tract by blocking interaction with integrin α4β7 [1]. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Crohn's disease |
Disease Ontology:
DOID:8778 OMIM: 266600 Orphanet: ORPHA206 |
Phase 2 clinical candidate for CD (see completed study NCT01298492). | |
Ulcerative colitis |
Disease Ontology:
DOID:8577 OMIM: 266600 Orphanet: ORPHA771 |
Phase 2 clinical candidate for UC (see NCT01771809). | 3 |