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Compound class:
Peptide or derivative
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Freer RJ, Day AR, Muthukumaraswamy N, Pinon D, Wu A, Showell HJ, Becker EL. (1982)
Formyl peptide chemoattractants: a model of the receptor on rabbit neutrophils. Biochemistry, 21 (2): 257-63. [PMID:6280748] |
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2. Stenfeldt AL, Karlsson J, Wennerås C, Bylund J, Fu H, Dahlgren C. (2007)
Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation, 30 (6): 224-9. [PMID:17687636] |
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3. Walther A, Riehemann K, Gerke V. (2000)
A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell, 5 (5): 831-40. [PMID:10882119] |
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4. Wenzel-Seifert K, Grünbaum L, Seifert R. (1991)
Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation. J Immunol, 147 (6): 1940-6. [PMID:1653806] |
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5. Wenzel-Seifert K, Seifert R. (1993)
Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. J Immunol, 150 (10): 4591-9. [PMID:8387097] |
